2025年12月5日，欧盟食品安全局（EFSA）发布消息，应欧盟委员会要求，欧盟食品安全局转基因生物（GMO）专家组就转基因玉米DP202216 × NK603 × DAS-40278-9用于食品和饲料中的安全性发表科学意见。

经过评估，转基因小组得出结论，就对人类和动物健康及环境的潜在影响而言，转基因玉米DP202216 × NK603 × DAS-40278-9与其传统对应品种和经过测试的非转基因玉米品种一样安全。部分原文报道如下：

Genetically modified maize DP202216 × NK603 × DAS 40278-9 was developed by crossing to combine three single events: DP202216, NK603 and DAS-40278-9. The three-event stack maize expresses PAT, CP4 EPSPS, CP4 EPSPS L124P, AAD-1 and the maize endogenous protein with altered expression (EPAE) ZMM28 to confer herbicide tolerance and to provide the potential for yield enhancement (PYE) under field conditions. The GMO Panel previously assessed the three single maize events and one of the sub-combinations and did not identify safety concerns. No new data on the single maize events or the assessed sub-combination were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins and the EPAE in the three-event stack maize does not give rise to food and feed safety or nutritional concerns. The GMO Panel concludes that three-event stack maize, as described in this application, is as safe as the non-GM comparator and non-GM reference varieties tested and no post-market monitoring of food/feed is considered necessary. In the case of the release of processed maize DP202216 × NK603 × DAS 40278-9 or accidental spillage of viable GM maize grains, into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in two of the maize sub-combinations not previously assessed and concludes that these are expected to be as safe as the single events, the previously assessed sub-combination and the three-event stack maize. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP202216 × NK603 × DAS 40278-9. The GMO Panel concludes that this three-event stack maize and its sub-combinations are as safe as its non-GM comparator and the tested non-GM reference varieties with respect to potential effects on human and animal health and the environment.

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